Member, Scientific Advisory Committee
Dr Isabella D. Cooper
PhD, AFHEA, MRSB
Biochemistry and medical pathophysiology scientist, University of Westminster
Dr Isabella Cooper is a biochemistry medical pathophysiology scientist at the University of Westminster, where she completed her degree in biochemistry and her PhD in hyperinsulinaemia and ketogenic science. Her KetoSAge clinical trial studies what happens to markers of ageing, insulin, growth factors and cancer risk when ketosis is suppressed in healthy women. She founded the Forever Young Group, a research collaboration spanning biochemistry, physiology, nutrition and pathology.
Areas of expertise
- Hyperinsulinaemia
- Therapeutic ketosis
- Metabolic ageing
- Cancer metabolism
Prevention areas their work supports
- Blood sugar & metabolic health
- Cancer
- Brain health
- Heart and stroke
Selected research
- Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females (opens in a new tab)
International Journal of Molecular Sciences, 2023
- Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm (opens in a new tab)
Biomedicines, 2021
- Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management (opens in a new tab)
Open Heart, 2020
See all 14 publicationsHide the full publication list
Peer reviewed papers: KetoSAge clinical trial series
- Ketosis Suppression and Ageing (KetoSAge) Trial: Effect of Hypoketonaemia on Extracellular Vesicle Profiles in Healthy Premenopausal Women (opens in a new tab)
Cooper ID, Petagine L, Cooper N, Soto-Mota A, et al. Clinical Bioenergetics, 2026
- Ketosis suppression and ageing (KetoSAge): the effect of suppressing ketosis on SHBG and sex hormone profiles in healthy premenopausal women, and its implications for cancer risk and therapy (opens in a new tab)
Cooper ID, Petagine L, Soto-Mota A, Duraj T, Seyfried TN, et al. Frontiers in Nutrition, 2026
- Ketosis Suppression and Ageing (KetoSAge): The Effect of Suppressing Ketosis on GKI and Liver Biomarkers in Healthy Females (opens in a new tab)
Cooper ID, Petagine L, Soto-Mota A, Duraj T, Norwitz NG, Seyfried TN, et al. Livers, 2025
- Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females (opens in a new tab)
Cooper ID, Kyriakidou Y, et al. Biomedicines, 2024
- Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females (opens in a new tab)
Cooper ID, Kyriakidou Y, Seyfried TN, Soto-Mota A, et al. International Journal of Molecular Sciences, 2023
Peer reviewed papers: reviews, hypothesis papers and other research
- Restoring Homeodynamics: Autophagy, Ageing and the Metabolic Correction of Disease (opens in a new tab)
Scarborough A, Kyriakidou Y, Lee DC, Duraj T, Seyfried TN, Cooper ID. BIOCELL, 2026
- Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model (opens in a new tab)
Cooper ID, Norwitz NG, Feldman D, Soto-Mota A, et al. Frontiers in Endocrinology, 2023
- Bio-Hacking Better Health: Leveraging Metabolic Biochemistry to Maximise Healthspan (opens in a new tab)
Cooper ID, Kyriakidou Y, Petagine L, Edwards K, Elliott BT. Antioxidants, 2023
- Rethinking Fragility Fractures in Type 2 Diabetes: The Link between Hyperinsulinaemia and Osteofragilitas (opens in a new tab)
Cooper ID, Brookler KH, Crofts CAP. Biomedicines, 2021
- Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm (opens in a new tab)
Cooper ID, Brookler KH, Kyriakidou Y, Elliott BT, Crofts CAP. Biomedicines, 2021
- Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men (opens in a new tab)
Kyriakidou Y, Cooper I, Kraev I, Lange S, Elliott BT. Frontiers in Physiology, 2021
- Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management (opens in a new tab)
Cooper ID, Crofts CAP, DiNicolantonio JJ, Malhotra A, et al. Open Heart, 2020
Encyclopedia entry
- Hyperinsulinaemia-Osteofragilitas (opens in a new tab)
Isabella D. Cooper. Encyclopedia (MDPI), 2021
Interviews
- Dr Isabella Cooper: Ketosis, hyperinsulinemia and more (opens in a new tab)
Podcast interview with Zoë Harcombe, March 2026