Professor Ben Bikman

2026

• Sugar-Specific Modulation of Trophoblast Function and Bioenergetics Under Metabolic Stress Conditions (opens in a new tab)

  Thurmond E, Boyer M, Bikman BT, Reynolds PR, Arroyo JA. Int J Mol Sci, 2026

• β-Hydroxybutyrate Maintains Energetically Demanding Neural Functions During Exogenous Glucose Deprivation (opens in a new tab)

  Ricks RL, Nevers DS, Hansen JM, Bikman BT, Parrish RR, et al. Cell Mol Neurobiol, 2026

• Understanding the Metabolic and Endocrine Effects of Macronutrient Boluses in the Context of a Low-Carbohydrate Diet: A Randomized Crossover Study (opens in a new tab)

  Deru LS, Bailey BW, Hales KE, Merrill RM, Bikman BT, et al. Nutrients, 2026

• Insulin Resistance: Current State of Knowledge and Clinical Implications—Toward a Better Diagnostic Framework and the Question of Its Disease Status (opens in a new tab)

  Rodzeń Ł, Rodzeń M, Fazio S, Unwin D, Bikman B, et al. Nutrients, 2026

• The Ketogenic Diet in the Prevention and Treatment of Hypertension (HTN) (opens in a new tab)

  Rodzeń Ł, Dyńka D, Bikman B, Unwin J, Fazio S, et al. Biomedicines, 2026

• Nr4a3 deficiency disrupts MEK1-ERK1/2-Drp1 signaling, driving adiposity and glucose intolerance in male mice (opens in a new tab)

  Ellsworth PN, Whalen KE, Yang Q, Bikman BT, Tessem JS, et al. Am J Physiol Endocrinol Metab, 2026

• Sweet apple e-cigarette vapor differentially modulates the mTOR pathway in oral squamous cell carcinoma cell lines (opens in a new tab)

  Vu K, Ponder L, Bikman BT, Reynolds PR, Arroyo JA, et al. Front Oncol, 2026

• Cyclic Altitude Training, Mitochondrial Health, and the Oral-Airway Axis: Intermittent Hypoxia Between Adaptation and Disease (opens in a new tab)

  Cannon M, Peldyak J, Reynolds PR, Bikman B. J Clin Med, 2026

• Personalized Combination of a Ketogenic Diet and Low-Dose Semaglutide for Cardiometabolic Health: A Retrospective Case Series (opens in a new tab)

  Parker G, Morris MD, Morris TJ, Reynolds PR, Bikman BT, et al. J Pers Med, 2026

• Semaglutide Induces Oxidative Stress and Differentially Modulates mTOR-Dependent Growth and Invasion in Human Trophoblast Cell Models: Implications for Placental Function (opens in a new tab)

  Thurmond E, Roeth EJ, Bikman BT, Reynolds PR, Arroyo JA, et al. Curr Issues Mol Biol, 2026

• Testosterone Replacement Therapy in Women Is Associated with Improved Symptom Burden and Favorable Biomarker Changes: A Retrospective Observational Study (opens in a new tab)

  Elggren CW, Iverson CH, Morris MD, Bikman BT, Reynolds PR, et al. J Pers Med, 2026

• Disparate Hepatic Mitochondrial and Inflammatory Effects of Ketone Supplements (opens in a new tab)

  Morris TJ, Morris MD, D'Agostino DP, Reynolds PR, Bikman BT, et al. Nutrients, 2026

• Maternal lung inflammation and apoptosis following gestational exposure to secondhand smoke and E-cigarette vapor: Implications for maternal-fetal health (opens in a new tab)

  Hiatt O, Davidson BD, Bikman BT, Reynolds PR, Arroyo JA, et al. Exp Mol Pathol, 2026

2025

• Potential Use of VYN202, a Novel Small Molecular Bromodomain and Extra-Terminal Inhibitor, in Mitigating Secondhand Smoke (SHS)-Induced Pulmonary Inflammation (opens in a new tab)

  Sturgis KA, Davidson BD, Arroyo JA, Bikman BT, Reynolds PR, et al. Curr Issues Mol Biol, 2025

• Personalized Supplementation Is Associated with Reduced Inflammatory Biomarkers: A 12-Week Observational Study (opens in a new tab)

  Roeth E, Morris M, Richardson AW, Bikman BT, Reynolds PR, et al. Life (Basel), 2025

• Effect of Exogenous Ketones as an Adjunct to Low-Calorie Diet on Metabolic Markers (opens in a new tab)

  Roeth EJ, Parker G, Reynolds PR, Parrish RR, Bikman BT, et al. Nutrients, 2025

• Pharmacological inhibition of all known major inward cationic currents does not block the induction of spreading depolarizations (opens in a new tab)

  Withers PC, Jones A, Bikman BT, Suli A, Parrish RR, et al. Front Cell Neurosci, 2025

• Comparative Effects of Cigarette Smoke and E-Cigarette Vapor on Oral Squamous Cell Carcinoma: Unraveling Distinct Molecular Pathways (opens in a new tab)

  Kinney R, Ponder L, Bikman B, Reynolds PR, Arroyo JA, et al. Dent Res Oral Health, 2025

• RAGE Knockout Mitigates Diet-Induced Obesity and Metabolic Disruption (opens in a new tab)

  Palmer IL, Parker G, Arroyo JA, Reynolds PR, Bikman BT, et al. Metabolites, 2025

• Impact of Secondhand Smoke and E-Cigarette Exposure on Placental Apoptotic and Growth-Regulatory Proteins in Mouse Pregnancy (opens in a new tab)

  Beck L, Kirkham MN, Shin M, Bikman BT, Reynolds PR, Arroyo JA. Cells, 2025

• Differential Regulation of PKM2, AMPK, and mTOR in Response to Insulin and Dietary Management (opens in a new tab)

  Broberg E, English J, Bikman BT, Reynolds PR, Arroyo JA, et al. Cells, 2025

• Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC) (opens in a new tab)

  Radford JH, Evans EP, Edwards IT, Arroyo JA, Bikman BT, Reynolds PR. Nutrients, 2025

• The Incretin Effect of Yerba Maté (Ilex paraguariensis) Is Partially Dependent on Gut-Mediated Metabolism of Ferulic Acid (opens in a new tab)

  Cooper-Leavitt ET, Shin MJ, Arroyo JA, Reynolds PR, Bikman BT, et al. Nutrients, 2025

• Transcriptomic Insights into Gas6-Induced Placental Dysfunction: Gene Targets for Preeclampsia Therapy (opens in a new tab)

  Jackson M, Gibson TM, Bikman BT, Pickett BE, Arroyo JA, et al. Cells, 2025

2024

• The Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and Metabolic Consequences of Uric Acid (opens in a new tab)

  Remund NP, Larsen JG, Johnson RJ, Reynolds PR, Bikman BT, et al. Metabolites, 2024

• Temporal RAGE Over-Expression Disrupts Lung Development by Modulating Apoptotic Signaling (opens in a new tab)

  Clarke DM, Kirkham MN, Bikman BT, Arroyo JA, Reynolds PR, et al. Curr Issues Mol Biol, 2024

• Differential Rates of Glycation Following Exposure to Unique Monosaccharides (opens in a new tab)

  Clarke DM, Koutnik AP, Johnson RJ, Bikman BT, Reynolds PR, et al. Int J Mol Sci, 2024

• The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet (opens in a new tab)

  Cayabyab KB, Shin MJ, D'Agostino DP, Norwitz NG, Bikman BT, et al. Nutrients, 2024

• Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms (opens in a new tab)

  Kirkham MN, Cooper C, Bikman B, Reynolds PR, Arroyo JA, et al. Cells, 2024

• Differential Inflammatory Cytokine Elaboration in Serum from Brick Kiln Workers in Bhaktapur, Nepal (opens in a new tab)

  Curtis KL, Chang A, Bikman BT, Arroyo JA, Reynolds PR, et al. Diseases, 2024

• Opinion: Are mental health benefits of the ketogenic diet accompanied by an increased risk of cardiovascular disease? (opens in a new tab)

  Diamond DM, Mason P, Bikman BT. Front Nutr, 2024

• Embryonic Mice with Lung-Specific RAGE Upregulation Have Enhanced Mitochondrial Respiration (opens in a new tab)

  Clarke DM, Curtis KL, Bikman BT, Arroyo JA, Reynolds PR, et al. J Respir, 2024

• The Effect of Diesel Exhaust Particles on Adipose Tissue Mitochondrial Function and Inflammatory Status (opens in a new tab)

  Warren CE, Campbell KM, Reynolds PR, Arroyo JA, Bikman BT, et al. Int J Mol Sci, 2024

• Antenatal Secondhand Smoke (SHS) Exposure and the Receptor for Advanced Glycation End-Products (RAGE) (opens in a new tab)

  Curtis KL, Hirschi KM, Bikman BT, Reynolds PR, Arroyo J, et al. Reprod Med, 2024

• The Effects of a High-Carbohydrate versus a High-Fat Shake on Biomarkers of Metabolism and Glycemic Control When Used to Interrupt a 38-h Fast: A Randomized Crossover Study (opens in a new tab)

  Deru LS, Gipson EZ, Bikman BT, Horne BD, Bailey BW, et al. Nutrients, 2024

2023

• Ceramides Mediate Insulin-Induced Impairments in Cerebral Mitochondrial Bioenergetics in ApoE4 Mice (opens in a new tab)

  Carr ST, Saito ER, Walton CM, Trumbull AM, Bikman BT, et al. Int J Mol Sci, 2023

• Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice (opens in a new tab)

  Walton CM, Saito ER, Reynolds PR, Hansen JM, Bikman BT, et al. Nutrients, 2023

• The Effects of Exercise on Appetite-Regulating Hormone Concentrations over a 36-h Fast in Healthy Young Adults: A Randomized Crossover Study (opens in a new tab)

  Deru LS, Chamberlain CJ, Bikman BT, Tucker LA, Bailey BW, et al. Nutrients, 2023

• Insulin receptor-inspired soluble insulin binder (opens in a new tab)

  Mendoza C, Hanegan C, Case T, Bikman B, Mizrachi D, et al. Eur J Cell Biol, 2023

2022

• A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice (opens in a new tab)

  Saito ER, Warren CE, Hanegan CM, Edwards JG, Bikman BT, et al. Metabolites, 2022

• Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet (opens in a new tab)

  Diamond DM, Bikman BT, Mason P. Curr Opin Endocrinol Diabetes Obes, 2022

• A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration (opens in a new tab)

  Bikman BT, Shimy KJ, Apovian CM, Ebbeling CB, Ludwig DS, et al. Eur J Clin Nutr, 2022

2021

• The Metabolic Effects of Ketones (opens in a new tab)

  Bikman BT, Fisher-Wellman KH. Int J Mol Sci, 2021

• The Effects of Exercise on β-Hydroxybutyrate Concentrations over a 36-h Fast: A Randomized Crossover Study (opens in a new tab)

  Deru LS, Bikman BT, Davidson LE, Tucker LA, Bailey BW, et al. Med Sci Sports Exerc, 2021

• Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression (opens in a new tab)

  Saito ER, Miller JB, Cruchaga C, Kauwe JSK, Bikman BT, et al. Alzheimers Dement, 2021

2020

• Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics (opens in a new tab)

  Walton CM, Jacobsen SM, Thomson DM, Hyldahl RD, Bikman BT, et al. Int J Mol Sci, 2020

• Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance (opens in a new tab)

  Chen T, Hill JT, Bikman BT, Hansen JM, Thomson DM, et al. Biochim Biophys Acta Mol Basis Dis, 2020

• Testing the carbohydrate-insulin model in mice: The importance of distinguishing primary hyperinsulinemia from insulin resistance and metabolic dysfunction (opens in a new tab)

  Ludwig DS, Ebbeling CB, Bikman BT, Johnson JD. Mol Metab, 2020

• Growth arrest-specific protein-6/AXL signaling induces preeclampsia in rats (opens in a new tab)

  Hirschi KM, Tsai KYF, Bikman BT, Reynolds PR, Arroyo JA, et al. Biol Reprod, 2020

2019

• Diesel Exhaust Particle Exposure Compromises Alveolar Macrophage Mitochondrial Bioenergetics (opens in a new tab)

  Gibbs JL, Dallon BW, Arroyo JA, Reynolds PR, Bikman BT, et al. Int J Mol Sci, 2019

• Differential placental ceramide levels during gestational diabetes mellitus (GDM) (opens in a new tab)

  Mejia JF, Hirschi KM, Bikman BT, Reynolds PR, Arroyo JA, et al. Reprod Biol Endocrinol, 2019

• Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet (opens in a new tab)

  Walton CM, Perry K, Hart RH, Berry SL, Bikman BT. J Diabetes Res, 2019

• Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization (opens in a new tab)

  Fox JC, Evans AT, Hill JT, Bikman BT, Hansen MDH, et al. Bioorg Med Chem Lett, 2019

• The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for Lipogenesis vs. Respiration in Saccharomyces cerevisiae (opens in a new tab)

  DeMille D, Pape JA, Bikman BT, Ghassemian M, Grose JH. G3 (Bethesda), 2019

2018

• Per-Arnt-Sim Kinase (PASK) Deficiency Increases Cellular Respiration on a Standard Diet and Decreases Liver Triglyceride Accumulation on a Western High-Fat High-Sugar Diet (opens in a new tab)

  Pape JA, Newey CR, Bikman BT, Bridgewater LC, Grose JH, et al. Nutrients, 2018

• β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle (opens in a new tab)

  Parker BA, Walton CM, Thomson DM, Tessem JS, Bikman BT, et al. Int J Mol Sci, 2018

• Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice (opens in a new tab)

  Dallon BW, Parker BA, Hodson AE, Tippetts TS, Bikman BT, et al. Biochem J, 2018

2017

• Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration (opens in a new tab)

  Rowley TJ 4th, Bitner BF, Bikman BT, Neilson AP, Tessem JS, et al. J Nutr Biochem, 2017

• β-Hydroxybutyrate improves β-cell mitochondrial function and survival (opens in a new tab)

  Sampson M, Lathen DR, Dallon BW, Tessem JS, Bikman BT, et al. J Insulin Resist, 2017

• Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration (opens in a new tab)

  Banks CJ, Rodriguez NW, Torres MP, Bikman BT, Andersen JL, et al. Mol Cell Biol, 2017

• LPS from P. gingivalis Negatively Alters Gingival Cell Mitochondrial Bioenergetics (opens in a new tab)

  Napa K, Baeder AC, Witt JE, Reynolds PR, Bikman BT, et al. Int J Dent, 2017

• High-Mobility Group Box 1 Disrupts Metabolic Function with Cigarette Smoke Exposure in a Ceramide-Dependent Manner (opens in a new tab)

  Taylor OJ, Thatcher MO, Holland WL, Reynolds PR, Bikman BT, et al. Int J Mol Sci, 2017

• Cigarette smoke extract (CSE) induces RAGE-mediated inflammation in the Ca9-22 gingival carcinoma epithelial cell line (opens in a new tab)

  Sanders NT, Dutson DJ, Arroyo JA, Bikman BT, Reynolds PR, et al. Arch Oral Biol, 2017

• Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure (opens in a new tab)

  Lewis JB, Hirschi KM, Arroyo JA, Bikman BT, Reynolds PR, et al. Int J Mol Sci, 2017

• What nutrition-related knowledge, skills, and attitude should medical students develop?

  Lindsley JE, Abali EE, Bikman BT, Wisco JJ, Thompson K, et al. Med Sci Educ, 2017;27(4):579–583. (no DOI)

• Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals (opens in a new tab)

  Mathis AD, Naylor BC, Miller BF, Bikman BT, Price JC, et al. Mol Cell Proteomics, 2017

2016

• β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion (opens in a new tab)

  Reynolds MS, Hancock CR, Ray JD, Bikman BT, Tessem JS, et al. Am J Physiol Endocrinol Metab, 2016

• Oral Gingival Cell Cigarette Smoke Exposure Induces Muscle Cell Metabolic Disruption (opens in a new tab)

  Baeder AC, Napa K, Winden DR, Reynolds PR, Bikman BT, et al. Int J Dent, 2016

2015

• Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function (opens in a new tab)

  Hodson AE, Tippetts TS, Bikman BT. Cardiovasc Diabetol, 2015

• Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism (opens in a new tab)

  Hansen ME, Simmons KJ, Tippetts TS, Thatcher MO, Bikman BT, et al. Shock, 2015

• Volumetric analysis of central body fat accurately predicts incidence of diabetes and hypertension in adults (opens in a new tab)

  Gibby JT, Njeru DK, Merrill RM, Bikman BT, Gibby WA, et al. BMC Obes, 2015

• MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance (opens in a new tab)

  Kwon OS, Tanner RE, Bikman BT, O'Connell RM, Drummond MJ, et al. Am J Physiol Endocrinol Metab, 2015

• Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner (opens in a new tab)

  Nelson MB, Swensen AC, Winden DR, Bikman BT, Reynolds PR, et al. Am J Physiol Heart Circ Physiol, 2015

2014

• Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration (opens in a new tab)

  Tippetts TS, Winden DR, Swensen AC, Reynolds PR, Bikman BT, et al. BMC Cardiovasc Disord, 2014

• Ceramides mediate cigarette smoke-induced metabolic disruption in mice (opens in a new tab)

  Thatcher MO, Tippetts TS, Nelson MB, Reynolds PR, Bikman BT, et al. Am J Physiol Endocrinol Metab, 2014

• Insulin increases ceramide synthesis in skeletal muscle (opens in a new tab)

  Hansen ME, Tippetts TS, Anderson MC, Prince JT, Bikman BT, et al. J Diabetes Res, 2014

• A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1 (opens in a new tab)

  DeMille D, Bikman BT, Mathis AD, Prince JT, Grose JH, et al. Mol Biol Cell, 2014

2013

• Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle (opens in a new tab)

  Smith ME, Tippetts TS, Kane DA, Prince JT, Bikman BT, et al. Biochem J, 2013

2012

• AICAR inhibits ceramide biosynthesis in skeletal muscle (opens in a new tab)

  Erickson KA, Smith ME, Prince JT, Hancock CR, Bikman BT, et al. Diabetol Metab Syndr, 2012

• Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro (opens in a new tab)

  Siddique MM, Bikman BT, Wang L, Wenk MR, Summers SA, et al. PLoS One, 2012

• Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis (opens in a new tab)

  Bikman BT, Guan Y, Holland WL, Wenk MR, Summers SA, et al. J Biol Chem, 2012

• A role for sphingolipids in the pathophysiology of obesity-induced inflammation (opens in a new tab)

  Bikman BT. Cell Mol Life Sci, 2012

2011

• Ceramides as modulators of cellular and whole-body metabolism (opens in a new tab)

  Bikman BT, Summers SA. J Clin Invest, 2011

• Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice (opens in a new tab)

  Holland WL, Bikman BT, Wang LP, Scherer PE, Summers SA, et al. J Clin Invest, 2011

• Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin (opens in a new tab)

  Holland WL, Miller RA, Bikman BT, Summers SA, Scherer PE, et al. Nat Med, 2011

2010

• Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKbeta Action in a Fiber-Type Specific Manner (opens in a new tab)

  Bikman BT, Zheng D, Kane DA, Neufer PD, Cortright RN, et al. J Obes, 2010

• Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats (opens in a new tab)

  Kane DA, Anderson EJ, Bikman BT, Cortright RN, Neufer PD, et al. Free Radic Biol Med, 2010

• Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment (opens in a new tab)

  Bikman BT, Zheng D, Reed MA, Hickner RC, Houmard JA, Dohm GL. Am J Physiol Regul Integr Comp Physiol, 2010

2009

• High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity (opens in a new tab)

  Bikman BT, Woodlief TL, Britton SL, Koch LG, Cortright RN, et al. Int J Sports Med, 2009

2008

• Mechanism for improved insulin sensitivity after gastric bypass surgery (opens in a new tab)

  Bikman BT, Zheng D, Pories WJ, Houmard JA, Dohm GL, et al. J Clin Endocrinol Metab, 2008

2007

• Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density (opens in a new tab)

  Stob NR, Seals DR, Bikman BT, Bell C, et al. Exp Physiol, 2007

• The Plagues of Prosperity (opens in a new tab)

  Bikman B. BYU Forum address, 17 July 2018

• Inflammation and the Metabolic Syndrome

  Bressler MA, Bikman BT. Asia Pacific Biotech News, December 2011 (magazine article)

• Sphingolipids and hepatic steatosis (opens in a new tab)

  Bikman BT, Summers SA. Chapter in Sphingolipids and Metabolic Disease (Advances in Experimental Medicine and Biology, vol. 721). Springer/Landes Bioscience, 2011